Computer freezes. They're probably at the top of everybody's gmg lists but some instances are more inopportune than others. Like say when you're in the middle of a very important powerpoint presentation. Or when you're about to totally pwn someone in WoW.
They can also happen when you're surfing NSFW websites at work:

"sup jhobbs. how's your---woah what are you looking at?"
jhobbs said that if i posted this it would really grind his gears. In fact, he said it would really g-m-g.
gmg...it's spreading like wildfire.